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Publication: Creating evidence-based drug monographs and drug class reviews

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Delfini Co-founders: Michael E Stuart MD, President & Medical Director . Sheri Ann Strite, Managing Director & Principal

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Formulary: Creating evidence-based drug monographs and drug class reviews

Formulary®: a peer-reviewed drug management journal for managed care and hospital decision-maker

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Process steps and suggestions for creating drug monographs and drug class reviews in an evidence-based formulary system

Strite SA, Stuart ME, Urban S. Process steps and suggestions for creating drug monographs and drug class reviews in an evidence-based formulary system. Formulary. April 2008;43:135–145.

Given the high estimates of inappropriate healthcare decisions in this country and the well-documented evidence of inappropriate variations in healthcare, a well-functioning formulary system is of great importance. Bias in research tends to inflate or falsely report benefit in clinical trials of interventions by up to a relative 40% to 50%. Therefore, to ensure the adoption of products with valid and clinically useful outcomes, formulary systems should include in their processes the key steps used in evidence-based medicine, including the evaluation of therapeutic studies for bias and clinical usefulness to inform formulary decisions. This article outlines requirements and suggestions for obtaining studies with appropriate designs and acceptable methodology and execution, and emphasizes why such studies should be the basis for developing drug monographs and class reviews and informing decisions. (Formulary. 2008;43:135–145.)

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