DelfiniClick

Validity Detective
Mike
-o
mstuart@delfini.org

A cool click for evidence commentaries & quality improvement nibblets. Check here periodically for information and Clicks worth making...new! »

Volumes

Use of Evidence »

  • Quality of Care — From Variation to Improvement
  • Reporting the Evidence
  • Applying the Evidence

Quality of Evidence »

  • Observational Studies
  • Primary Studies & General Concepts
  • Screening & Diagnostic Studies
  • Secondary Studies
  • Secondary Sources

See On the Same Page for Patient-centered Resources »

  • General Help for Patient-centered Approaches
  • Online Resources for Patients, Clinicians & Others
  • Clinician + Patient Communications
  • Sample Communications: Text, Layout, Visual Aids

See Delfini Showcase: Publications for in various sources available online »

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Volume Contents

Use of Evidence

Quality of Care From Variation to Improvement »

  • The Volume of Inappropriate Care in the US
  • More On Therapies Becoming “Routine Clinical Practice” Without Evidence & Why We Are Doing This Work: Radiofrequency for the Treatment of Gastro-esophageal Reflux Disease Example
  • Variations in Experts' Recommendations
  • Variations in Clinicians' Estimates of Pretest Probabilities
  • Underuse of Proven Interventions
  • Class Effect: Caution Urged

Reporting the Evidence »

  • Untrustable Abstracts & P-Values
  • CONSORT Statement on Harms
  • When There is No Evidence
  • TREND: Reporting Standards for Non-randomized Studies
  • Poorly Written Papers
  • Media Heyday: Aspirin and (Potentially) Reduced Risk of Breast Cancer

Applying the Evidence »

  • Better Evidence Choices: Carotid Endarterectomy
  • Guidelines & Effectiveness of Implementation
  • Oregon Preferred Drug List
  • Successful Evidence-based QI Project: Diabetes Management at Dreyer Medical Clinical
  • Also see On the Same Page for applying the evidence through patient-centered resources »

Quality of Evidence

Observational Studies »

  • More on the Problem with Drawing Cause-Effect Conclusions from Observational Studies
  • Cause & Effect Conclusions from Observations
  • Bias in Observational Studies — More on HRT in Menopause

Primary Studies & General Concepts »

  • Quality of Studies: Lower Quality = Greater Effect Size
    • More: Overestimation of Effect Size in Studies of Low Quality
  • Concealment of Allocation
  • Blinding and RCTs
  • Blinding in Surgery Trials
  • The Importance of Blinded Assessors in RCTs
  • Attrition Bias: Intention-to-Treat Basics
  • Intention-to-Treat & Censoring: Rofecoxib Example
  • Intention-to-Treat Analysis: Misreporting and Migraine
  • Missing Data Points: Difference or No Difference
  • Quality of Studies: VIGOR
  • Confidence-Intervals, Power & Meaningful Clinical Benefit
  • Getting “Had” by P-values: Confidence Intervals vs P-values in Evaluating Safety Results: Low-molecular-weight Heparin (LMWH) Example
  • Understanding Number Needed to Treat (NNT)
  • Early Discontinuation of Clinical Trials: Oncology Medication Studies—Recent Developments and Concern

Screening & Diagnostic Studies »

  • The Bias of “Survival” in Cancer Screening Studies: CT Screening for Lung Cancer in Smokers—Back-to-Basics for Validity
  • Bias in Diagnostic Studies

Secondary Studies »

  • Systematic Reviews: Quality & Searching Tips
  • Systematic Reviews: Untrustable "Trustable" Sources?
    • Review of Cochrane Groups’ Assessment of Bias in Studies
  • Bell's Palsy Update
    • Delfini Letter to BMJ: Corticosteriods are Not Proven for Treatment of Bell's Palsy
    • Delfini Letter to NEJM: Bell's Palsy - REDUX!
  • Substandard Evidence: POEMS and Diabetes — Readers, Beware!
  • Quality of Systematic Reviews: Misleading “POEM” on Hormone Therapy

Secondary Sources »

  • Quality of Clinical Guidelines
  • Poor Quality of Guidelines: Case Study — The Evidence on Well-Child Care Recommendations
  • Another Cautionary Tale About Clinical Guidelines: Screening for Heart Attack Prevention and Education (SHAPE) Task Force Guidelines Example

See our other Delfini Newsletter...

Click here for
On the Same Page


Evidence-based Information & Decision Aid Examples for Health Care Professionals & Patients — Putting Everyone on the Same Page

Bulletin Board

new
05/08/08: Review of Cochrane Groups’ Assessment of Bias in Studies »

Other Information

For evidence-based medicine basics, see Evidence Essentials »

Delfini publications in various sources available online »

Delfini Recommended Reading for other EBM sources »

For other news and items specific to practitioner and patient information aids, see
On the Same Page
»

About PMID Numbers: We frequently utilize a PMID number in place of a citation. Where PMID numbers are available, enter that number into the PubMed search box to retrieve that citation and listing.

For Clicks that do not work, please email us to let us know. For many of them, you may be able to go to PubMed and do a quick search using the citation: www.PubMed.gov.

Validity Detectivette
Sherita
(or Sherois if you prefer a oui bit of French)
sstrite@delfini.org

 

 

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